SciBlogs

Posts Tagged $100Dialysis

Why you should care about Oregon John Pickering May 08

No Comments

Reblogged from Stray Thoughts:

Click to visit the original post

For those of you who haven’t heard, there is big news out of Oregon.

Oregon is a fascinating place right now for those interested in health policy, and here’s why: What amounts to a giant experiment on the expansion of Medicaid is taking place there as we speak. In 2008, Oregon had a limited amount of funding to expand Medicaid. There were far more people who wanted to join the Medicaid pool than could be funded.

Read more… 1,348 more words

I love the way this med student writes. This is a fascinating account of an “accidental” randomised controlled trial of government spending on health (Medicaid in the US).

Two new Health Research Council grants worth crowing about John Pickering May 07

No Comments

This week’s announcement by the HRC of Feasibility Study and Emerging Researcher grants have many great projects.  Two in particular are worth crowing about (because they have some relationship to kidneys and they involve two excellent people).  I have put summaries in their own words below, but first my comments.

Dr Palmer (Department of Medicine, University of Otago Christchurch), who has appeared on this blog site before, conducts what in the trade are called “meta-analyses” and “systematic reviews.”  Simply put, these are methods to extract the best possible evidence from all the studies that have been done for the effectiveness of a treatment.  Just as one person may toss a coin 4 times in a row and get 4 heads, so too can any one trial give a mistaken impression that a treatment is efficacious (or not) when it really isn’t (or is).  By pooling together many treatments Suetonia provides the very best quality evidence available.  Given that Chronic Kidney Disease affects a large and growing proportion of us, knowing which treatments have the best outcomes is of national significance, not merely to our health but also to the national budget.  A particular problem is that after a trial it can be many many years until meaningful health outcomes are know (e.g. if the treatment delays dialysis need or reduces mortality).  Suetonia’s study will assess the effectiveness of surrogate endpoints for clinical trials.  Surrogate endpoints, such as plasma creatinine which I’ve discussed many time in this blog, are physiologically related to the functioning of an organ or to a disease state as well as statistically associated with future hard outcomes.  However, their use in trials is limited by how well they are associated and how they are used.  I look forward to finding out what Suetonia discovers.

Mrs Rachael Parke (Auckland DHB) is an experienced nurse undertaking a PhD. Ensuring patients have adequate fluids on board is particularly crucial to the kidneys and other organs. Obviously with surgery any blood loss needs to be compensated for. However, there are also physiological changes in where fluid is distributed throughout the body.  Cardiopulmonary bypass, used in cardiac surgery, is a particular risk factor for Acute Kidney Injury. In the past the practice has been to give large amounts of fluid in order to ensure adequate fluid is given.  However, recent research has shown that too much fluid can have a negative impact (increased mortality).  A more restrictive fluid regime may have very meaningful outcomes.  Rachael is investigating, in a randomised controlled trial, if restricting fluid improves outcomes.  The outcome she is most interested in is how long patients stay in the hospital.  This is a very practical outcome for both patient and budget.  I am particularly pleased that this study is nurse-led.  Nurses play an incredibly important role in research as well as patient management.

In their own words:

Dr Suetonia Palmer: Making better clinical decisions to prevent kidney disease

More than ten percent of adults will develop chronic kidney disease. The effectiveness of many treatments used to improve outcomes in kidney disease is tested against surrogate (indirect) markers of health (e.g., cholesterol levels or blood pressure).

Unexpectedly, subsequent systematic analysis has identified little evidence to show that treatment strategies based on these surrogate markers translate to improved health for patients. Serum creatinine and proteinuria levels are commonly-used markers of kidney function to guide treatment.

The research involves using systematic review methods to summarise the quality of evidence for using proteinuria and serum creatinine as markers of treatment effectiveness in clinical trials. It will be determined whether using these markers to guide clinical care improves patient health or, conversely, leads to treatment-related harm or excessive use of ineffective medication.

These summaries will help clinicians and patients make better shared decisions about which therapeutic strategies actually improve clinical outcomes in kidney disease.

Mrs Rachel Parke: Fluid therapy after cardiac surgery – A feasibility study

Following cardiac surgery, patients receive large amounts of fluid in the intensive care unit. This may cause problems with wound healing and delay hospital discharge. A planned randomised controlled trial of a restrictive fluid regime as compared to a more liberal approach utilising advance hemodynamic monitoring, aims to reduce the amount of fluid patients receive and reduce hospital length of stay. This feasibility study aims to determine whether this nurse-led protocol is practicable and feasible and will help answer the research question. This study is simple and inexpensive and if it demonstrates a decreased length of hospital stay then this will represent a significant benefit for both individual patients and the health system.

Tagged: Acute Kidney Injury, auckland dhb, Cardiac Surgery, Cardiopulmonary Bypass, Chronic Kidney Disease, Intensive Care Unit, Kidney, Kidney Attack, metaanalysis, university of otago

Cooking up a new kidney John Pickering Apr 15

No Comments

The Boston Kidney Recipe

  1. Take an unwanted kidney.
  2. Disconnect from plumbing.
  3. Wash away cells (use plenty of detergent).
  4. Take resultant scaffold and reseed with a few cells obtained from someone needing the kidney.
  5. Place in bioreactor and “cook” for 3 to 5d (or until done)
  6. Place regenerated kidneys into the transplant recipient and connect to plumbing.
  7. Pee.

In Nature Medicine today Massachusetts General Hospital based researchers have announced the successful removal of an unwanted kidney from one rat, the removal of cells from that kidney, regeneration with stem cells from another rat, transplantation into that animal and the observation of  urine production*.  A  small step for a rat, a giant leap for anyone waiting for a transplant.  Why is this so important?  As the authors’ state:

“A bioengineered kidney derived from patient-derived cells and regenerated ‘on demand’ for transplantation could provide an alternative treatment for patients suffering from renal failure.”

While this study is “proof of context”, it is a beautiful proof and one which should bring hope to millions. There are many more people with End Stage Renal Disease than kidneys available for transplant.  Some donated kidneys currently considered not good for transplant may become viable in the future if the cells are stripped off and the patient’s own stem cells can be used to grow a new kidney over the scaffold of the old one.  By using the patient’s own cells the immune response may be reduced.  This will mean less dependence of immunosuppressant drugs and therefore fewer side effects, including  cancer, and less transplant rejection. This is the vision and one that can not come soon enough.  Have a look at the video and if you want to get into details, check out the paper* .

*Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Jeremy J Song, Jacques P Guyette, Sarah E Gilpin, Gabriel Gonzalez, Joseph P Vacanti & Harald C Ott1. Nature Medicine. Advance Publication Online. http://dx.doi.org/10.1038/nm.3154

Tagged: bioengineering, End Stage Renal Disease, End stage renal failure, Kidney, Renal Failure, Transplant, Urine

The Face of Kidney Attack Part II John Pickering Apr 10

No Comments

This guy crawls through bat dung for fun.  He also runs incredibly long distances and then cycles or kayaks more.  If you’ve not guessed already, our Face of Kidney Attack is multisport and adventure racer Sir Steve Gurney (He’s not really “Sir” but anyone who does what he does deserves some sort of honorific and all other honorifics he’s been called are not printable).

For those of you who are not New Zealanders or who were asleep the last couple of decades, Steve made his name in the incredible Coast-to-Coast race which involves cycling, kayaking and mountain running from the West to East coast of the South Island of New Zealand through the Southern Alps.  Arduous does not begin to describe this race – that Steve does it in under 12 hours and has won the race 9 times are mere numbers which can not possibly describe the punishment he put his body through and the mental toughness he developed.  However, in 1990 a Kidney Attack almost halted the adventure and very nearly killed Steve.

In the 90s Raid Gauloises were the toughest races of them all. Now known as Adventure races they involve hiking, mountain biking, canoeing, and scrabbling across the toughest terrain for days on end.  The first race in 1989 had been the NZ Grand Traverse. The lure of such a race in Borneo with Christchurch adventure race guru John Howard was too much for Steve in 1994 – a prize of $55,000 was a pretty good incentive as well.  John and Steve arrived in Borneo where John had arranged for three Malaysian athletes to join them (all adventure race novices).  The race was expected to take 10 days.  The race was famous for four things, first John organised the team to take minimal equipment and supplies – previously heavily laden backpacks had been the order of the days, second John and Steve became the first athletes to win two such races, third they did the race in 5 days not the expected 10, and fourth, is what happened to Steve.

Early in the race Steve suffered heat stroke having mountain biked up a steep hill (just to show he could, the others walked their bikes!).  He vomited and was quite sick.  Water was in short supply (remember they took minimum supplies) and it was very humid “jungle” weather.   This was the first “hit” his kidneys took – dehydration is not good.  One of the primary roles of the kidney is to regulate body water so as to keep the right balance between water and salts.  This process was obviously under stress as Steve lost water through vomiting and sweat and may not have replaced enough.

Later in the race the racers had to crawl through the Mulu caves.  This was an 8 hour trek that involved getting down on hands and knees and squeezing through gaps in the rock.  The caves were home to bats and the floor was covered in bat dung.  By the time they finished the trek Steve, wearing shorts at the time, was covered in scratches.  It is likely that here he picked up the bacteria  that causes leptospirosis from the bat dung. “Hit” number two. This is an infectious bacterial disease which grows great in neutral or acidic pH as found in renal tissue.  The body’s response is inflammation, hypotension (low blood pressure), decrease blood flow to the kidneys (low oxygen to the tissue, therefore death to cells), and decrease in renal filtration.  There can also be direct invasion of renal cells causing necrosis. The severity of disease determines severity of the kidney attack.

Hospital2 Hospital3While the Kidney Attack began during the race, it was not until a few days later Steve got real sick.  As the team waited for the other teams to finish, he began to feel unwell – fever and headaches.  He was determined to enjoy the post race party on Saturday 29th October, so took a couple of aspirin (!).  He made it to the party, but only just. By Sunday afternoon his friends were in emergency mode organising for him to get on a flight to reach the nearest hospital in Kuching.  Steve quite literally crawled off the plane and waited for an ambulance to take him to hospital.  It was a small hospital and after 5 days, most of it sedated, without improvement, Steve was evacuated to Mt Sinai Hospital in Singapore.  There leptospirosis was diagnosed (it’s difficult to diagnose because of similarity of symptoms with other diseases of the tropics like typhus, dengue fever, Hanta virus infection).  Steve spent 10 days in ICU undergoing regular dialysis to support his kidneys and nearly all the time under sedation.  He was very lucky to survive.  His story of leaving Singapore, a $91,000 medical bill*, and continued hospitalisation in Christchurch with further dialysis is a harrowing one and can be found in his autobiography, “Lucky Legs.”

In the next instalment of the Face of Kidney Attack I will look at life after Kidney Attack.

__________________

*Steve had insurance provided by the race organisers, but it was woefully inadequate.  Only with the support of friends, family, and a public appeal did he avoid loosing his house.  I’ve considerable experience in assessing medical and travel insurances (long story why).  Never travel without at least $500,000 medical cover and preferably unlimited!  I choose myself to use Uni-Care outbound (http://www.uni-care.org)

Tagged: Acute Kidney Injury, Acute Renal Failure, Kidney, Kidney Attack, leptospirosis, Mulu Cave, Steve Gurney

The Face of Kidney Attack John Pickering Apr 03

No Comments
The Face of Acute Kidney Injury.  (Published with permission).

The Face of Acute Kidney Injury. (Published with permission).

It ain’t pretty, it’s Acute Kidney Injury.  This case was probably brought on by leptospirosis.  This is the face of a well known New Zealander.  Do you recognise him?  He’s kindly lent his name to my research on AKI.  I will reveal that name in future posts as I tell his remarkable story.

Tagged: Acute Kidney Injury, Acute Renal Failure, AKI, ARF, health, hospital, Kidney Attack, leptospirosis

Kidneys Are The Hardest Workers In Your Body John Pickering Mar 15

No Comments

Reblogged from Factographs:

Click to visit the original post

World Kidney Day — March 14 this year — is a worldwide awareness campaign that aims to draw attention to kidney disease. Yet another awareness campaign? Yes, we’re afraid so. But this one isn’t pointless. Kidney disease affects a lot of people throughout the globe, and around 10 percent of US adults.

Because the symptoms are initially so vague, many have no idea they suffer from kidney disease until it has reached a serious stage and complications can no longer be prevented.

Read more… 59 more words

Love this info graphic

Diabetes in NZ – new scary data John Pickering Mar 01

4 Comments

If this doesn’t scare you, you are an Ostrich.  Otago University researcher Dr Kirsten Coppell has released new data on the prevalence of diabetes in New Zealand.  See here for the press release.

Basic data:

  • 7% of New Zealanders over the age of 15 have diabetes
  • 18.6% have pre-diabetes which typically leads to Type II diabetes (therefore the prevalence is likely to go higher than 7%).
  • The pre-diabetes prevalence increases with age – it was 45% in 55-64 year age group.

For those interested in reading the research, it can be found in the NZ Medical Journal.  NZMJ 1 March 2013, Vol 126 No 1370; ISSN 1175 8716  URL: http://journal.nzma.org.nz/journal/126-1370/5555/  Dr Coppell kindly sent me a copy (*I’ve made a few more observations about the details of the study for those who are interested below).

In the meantime, this is rightly hitting the headlines.  We should be afraid, very afraid.  Our politicians must stop arguing over that which is petty (like selling less than half of a small fraction of our assets) and get focussed on what matters.  Next year is election year – we should demand a comprehensive diabetes policy from each political party.  Below is a letter I wrote to the Christchurch Press prior to the last election – not much has changed.  As for you – you can stop attacking the sugar – you don’t need it and it may kill you.  Beware of “fat free” food which substitutes sugar instead.  Get some advice – see your doctor.  Don’t become a statistic in the next survey.

As for the link with my work (Kidney Attack a.k.a. Acute Kidney Injury), the little diagram explains.Diabetes AKI

378524_2646852331216_1123939800_n

________________________

*  The study was a representative sample of New Zealanders.  The study size was large (for an NZ study) – 4,721.

From the results

Overall the prevalence of diabetes was 7.0% (95% CI: 6.0, 8.0). Diabetes was more common among men (8.3%; 95% CI: 6.4, 10.1) compared with women (5.8%; 95% CI: 4.7, 7.0). The prevalence of diagnosed diabetes was 6.0% (95% CI: 4.5, 7.5) among men and 4.0% (95% CI: 3.1, 4.8) among women, and the prevalence of undiagnosed diabetes was 2.1% (95% CI: 1.2, 3.0) among men and 1.5% (95% CI: 1.0, 2.0) among women.

Scary for me is the percentage of undiagnosed diabetes.  This represents tens of thousands of New Zealanders!

Tables in the paper show how the prevalence increases with age and body mass index and that there are marked differences according to ethnicity.  One third of Pacific people over the age of 45 had diabetes, yet about 40% of this was undiagnosed diabetes!

By the way – 95% CI with two numbers following means a that the 95% confidence interval for the prevalence is between the two numbers.  What this means is that there is a 95% chance that confidence interval contains the true prevalence (which can only be known if everyone is measured).  Eg There is a 95% chance that the 6% to 8% confidence interval contains the true prevalence of diabetes (note – 7% should be thought of as an estimate).

Tagged: Acute Kidney Injury, AKI, Chronic Kidney Disease, Diabetes, End stage renal failure, Kidney Attack

Live from UOC 40th anniversary lectures John Pickering Feb 20

No Comments

This afternoon I have heard presentations from seven former students of the Christchurch Med School (University of Otago Christchurch), almost all now Professors.  It has been fascinaying and moving.

1.00 – 1.25 Professor Vicky Cameron, Cardiovascular risk factors in Maori and non- Maori communities: Strategies for improved clinical management’ 

Fascinating comparision between an urban Maori, Rural Maori and urban non-Maori cohort.  Despite  good access to primary care  and little access to fast food outlets urban Maori were exhibiting the highest risk factors.

1.25 – 1.45 Mr Tim Eglinton, ‘Starting at the bottom and working up: Perianal Crohn’s Disease in Canterbury’

Canterbury has one of the highestrates of Chrons disease in the world!

1.45 – 2.15 Dr Quentin Durward, ‘The Crash of United Flight 232 in Sioux City, Iowa, July 19 1989: Community and Medical Response to a Mass- Casualty Commercial Airliner Disaster’

Very moving account of dealin with an air disaster.  Fortunately there was a great plan in place.

2.15 – 2.45 Professor Michael Ardagh, ‘After the dust settles – researching the health implications of seismic events’

Also very moving.  Prof Ardagh is head of the Emergency Department here.  He talked about the response to the earthquake.  Again the importance of a plan can not be overesimated.     Who knew that during those first few hours the blood bank was still processing requests while ankle deep in water, suffering power outages, in a basement of a very shakey multistory building, all at the same time as not knowing about  their own families?  More heroes unsung!

 

Afternoon sessions

Come tomorrow.

Chair: Professor Lisa Stamp

3.30 – 4.00 Professor Brian Darlow, ‘From small to

big – clinical research in newborn medicine’

4.00 – 4.30 Professor Rob Walker, ‘Nephrology: Ross Bailey – Drugs and the Kidney’

4.30 – 5.00 Professor Bridget Robinson, ‘Keeping Cancer Research Close to the Patient’ 

Tagged: health, university of otago

30,000 John Pickering Feb 08

No Comments

Today’s number brought to you by <You could have your name here, contact the blog writer to arrange sponsorship>

30,000 – the number of Kidney Attacks in New Zealand each year.

30000

Where does this number come from?

Research in other parts of the world has Kidney Attack, or Acute Kidney Injury, at ~5% of all hospital admissions.  Estimates range from 2% to >9%.  5% is the generally accepted incidence.  New Zealand has more than 1.1 million hospital admissions a year, with 410,000 of them day cases.  5% of the 690,000 longer stays is 34,500.  30,000 is, therefore, a conservative estimate.  The NZ health stats don’t report these numbers because they are not collected.  They are not collected because nearly always the cause for hospital admission is something else – heart attack, infection etc.  These “something elses” all can cause Kidney Attack.   Kidney Attack raises the chances of dying in hospital 4 fold.

I’d like to find the NZ incidence of Kidney Attack instead of relying on estimates based on overseas numbers.  In particular, I’d like to see if there are any differences related to ethnicity.  I’m searching for funding to do this.

Tagged: Acute Kidney Injury, AKI, Kidney, Kidney Attack, World Kidney Day

How many times do you wash your blood each day? John Pickering Feb 01

No Comments

Stop Kidney Attack.  See this great short video from last year’s World Kidney Day as to why it is so very very important to look after your kidneys. Or as Fred Dagg may sing “If it weren’t for your kidneys, where would you be? You’d be in the hospital or infirmary.”



Tagged: Acute Kidney Injury, Blood, Chronic Kidney Disease, Kidney, Kidney Attack, World Kidney Day

Network-wide options by YD - Freelance Wordpress Developer