Tagged: epigenetics

Find transcription factor motifs in genomes better: add histone acetylation data - Code for life

Grant Jacobs Oct 14, 2010

A ‘lite’ review of an attempt to improve motif screening of genomes using additional data. Considering local minima of histone acetylation in a context of high histone acetylation may be one way forward. A number of years ago at a biotechnology sector after-talk drinks I found myself trying to convince a CEO that often … Read More

Autism – looking for parent-of-origin effects - Code for life

Grant Jacobs Sep 16, 2010

Autism is probably one of the best known neurological disorders, in part due to promotion in Hollywood movies such as Rain Man. It is described in the On-line Mendelian Inheritance in Man (OMIM) database as being ‘characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, … Read More

Epigenetics and 3-D gene structure - Code for life

Grant Jacobs Aug 03, 2010

DNA methylation controls the binding of proteins that control the 3-D structure of genes. This is a lightly edited version of an article I wrote as a guest on Alison’s blog over a year ago, looking back a couple of years to show something of what epigenetics was bringing to genome biology. The … Read More

The scale of cellular life and compacting chromosomes - Code for life

Grant Jacobs Jul 11, 2010

It’s hard convey the scale of very small or very large things by just quoting measurements as the measurements don’t relate well to our perception of everyday objects. [caption id="attachment_2956" align="alignleft" width="327" caption="Snapshot from infographic (Source: University of Utah.)"][/caption] This interactive infographic presented by the Genetic Science Learning Centre at the University … Read More

Meeting – Nature, nurture and you - Code for life

Grant Jacobs Jun 18, 2010

A meeting covering the juncture of psychiatric and behavioural genetics, longitudinal, environmental, and intervention studies will be hosted by Genetics Otago and the Centre for Research on Children and Families in Dunedin (NZ) on July 19th. Below is a reduced – and hence slightly pixelated! – copy of the poster for the meeting. Original PDF copies of … Read More

Martin Raff on what is autism - Code for life

Grant Jacobs May 31, 2010

The open-access scientific journal BMC Biology is currently hosting an interview with Martin Raff, presenting his responses to questions about autism. Prof. Raff gives the background in simple form well. A neurobiologist with an excellent scientific pedigree Professor Raff did not study autism during his research career, but became interested in it after he retired … Read More

I remember because my DNA was methylated - Code for life

Grant Jacobs May 29, 2010

Our memories keep our yesterdays, our friends’ faces, the distinctive smell of previous partners, if we’ve read that book before, what clothes you wore to the party. Movies and books have been written about memories. Or the trials not being able to keep them.2 Poets and lyricists evoke them, talk about them and reminiscence … Read More

Epigenetics, a confused muddle in the media - Code for life

Grant Jacobs Mar 22, 2010

Guardian features writer Oliver Burkeman leads the on-line science section with a piece titled ’Why everything you've been told about evolution is wrong.’ [caption id="attachment_1708" align="alignright" width="206"] DNA (unmethylated). Source: wikipedia.[/caption] It’s caused something of a fuss amongst some in science writing circles, with replies by Adam Rutherford and Jerry Coyne. Read More