Tagged: research blogging

Find transcription factor motifs in genomes better: add histone acetylation data - Code for life

Grant Jacobs Oct 14, 2010

A ‘lite’ review of an attempt to improve motif screening of genomes using additional data. Considering local minima of histone acetylation in a context of high histone acetylation may be one way forward. A number of years ago at a biotechnology sector after-talk drinks I found myself trying to convince a CEO that often … Read More

Finding platypus venom - Code for life

Grant Jacobs Oct 07, 2010

Platypuses[1] are one of Australia’s oddest creatures. They’re furry, mainly nocturnal aquatic creatures that swim with their eyes shut paddling with their webbed front feet and steering (or braking) with their rear feet. Their homes are burrows in the river banks. While not endangered, water pollution is an issue for their survival.[2] … Read More

Autism – looking for parent-of-origin effects - Code for life

Grant Jacobs Sep 16, 2010

Autism is probably one of the best known neurological disorders, in part due to promotion in Hollywood movies such as Rain Man. It is described in the On-line Mendelian Inheritance in Man (OMIM) database as being ‘characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, … Read More

Coiling bacterial DNA - Code for life

Grant Jacobs Aug 24, 2010

A chain of proteins hold bacterial DNA in a compacted spiral. You and I are eukaryotes. Our cells have nuclei, repositories that contain our DNA and the proteins that read them to produce an RNA copy of them. [caption id="attachment_3694" align="alignleft" width="300"] HeLa cells* stained for DNA (Source: Wikimedia Commons.)[/caption] In earlier … Read More

Epigenetics and 3-D gene structure - Code for life

Grant Jacobs Aug 03, 2010

DNA methylation controls the binding of proteins that control the 3-D structure of genes. This is a lightly edited version of an article I wrote as a guest on Alison’s blog over a year ago, looking back a couple of years to show something of what epigenetics was bringing to genome biology. The … Read More

The roots of bioinformatics - Code for life

Grant Jacobs Aug 02, 2010

I’d like to bring to wider attention an article series, The Roots of Bioinformatics. The roots of prairie plants (Source: Wikimedia Commons.) Hold up. Before experimental biologists run away, you’re some of the people I’d like this to reach! At a recent bioinformatics meeting I attended, a senior experimental biologist from overseas commented to … Read More